Chemistry
With a force of nearly 1300 Synthetic and Medicinal Chemists, ChemPartner is amongst the largest and most experienced Chemistry Service Organizations in China. We have over 12-year experience in working with hundreds of pharmaceutical and biotechnology companies.

  • Strong expertise in Medicial Chemistry
  • Extensive experiences in custom synthesis, library synthesis and etc
  • Ready-to-go screening assays
  • Extensive experience in integrated services
  • CMC

For more information, please visit Chemistry.

Antibody Discovery
Chempartner has a comprehensive antibody discovery team for antibody drug development. With over 160 scientists, 30 of which are PhD/MDs, we aim to cover all the areas where our clients have needs.

  • High-affinity antibody
    • Hydridoma
    • Phage display
    • Human Ig transgenic mouse
  • Fully-human antibody
  • Affinity matured antibody
  • Comprehensive screening and characterization package
    • Binding assays
    • Functional assays
  • Antibody-drug conjugate
  • Experience in immune modulator drug development
  • Extensive experience in integrated services
  • Antibody CMC

For more information, please visit Antibody Discovery.

DMPK
  • Bioanalyses of biomarkers
  • PK/PD in small animals
  • PK study in large animals
  • PK/PD correlations
  • Analyses of clinical samples

For more information, please visit DMPK

In Vitro and Cell-Based assays
To facilitate the Tumor Immunology integrated services, the In Vitro Biology and Cell Biology each provides extensive types of screening assays and are ready to develope new assays for our clients.

  • Biochemistry screening
    • Off-the shelf assays
    • High-throughput screening
    • Extensive experience in assay development
  • Cell based assays
    • Screening assays in target-expressing or -transfected cell lines
    • Human PBMC assays: antigen recall assay; MLR assays
    • Mouse lymphocyte assays: proliferation, cytokine secretion
    • Co-culture assays

For more information, please visit In Vitro Biology and Cell Biology

Pharmacology
In vitro:

  • Primary immune assays using isolated T cells or other immune subsets:
  • Proliferation assays
  • Cell surface marker profiling
  • Intracellular cytokine staining by flow cytometry, or cytokine measurements from cultured T cell supernatant by ELISA or Luminex
  • MLR
  • Antigen-recall assays
  • Others

In vivo: Syngeneic models (for small molecules, cross-reactive or surrogate antibody development):

  • More than 20 syngeneic tumor models including some of the most widely used models, such as CT26, MC-38, 4T1, B16F10, RENCA, EMT6, LLC, A20 and more.
  • Orthotopic and metastasis models

Humanized mouse models:

  • Adoptive transfer of human PBMC into immune compromised animals (under optimization)
  • Human target knock-in: PD-1, CTLA-4, and more to come

Ex vivo analyses:

  • Tumor infiltrating lymphocytes (TILs) or myeloid cells
  • Lymphoid tissues such as spleen, tumor draining lymph nodes (TDLNs)
  • Lymphocyte composition and surface marker profiling: CD4, CD8, Treg, and myeloid-derived suppressor cells
  • Cytokine measurements
  • Ex vivo functional assays

For more information, please visit Oncology