Our new, 23,000 sqft laboratory facility in South San Francisco bridges the China-based research engine with our US-based clients. This built for purpose research facility is home to scientific experts who provide technical guidance and support for early discovery research.
We offer several models for collaboration including full time equivalent (FTE) support, a US-China blended team of scientific expertise, and hourly consulting.
Our entire team is Ph.D.-qualified and our scientists each have more than 15 years of experience in the biopharmaceutical industry. We are experienced with Medicinal Chemistry, Computational Chemistry, Peptide Chemistry, Biology, ADME, and Biologics. The global directors of computational chemistry/structural biology and Analytical Chemistry are located at this site in South San Francisco.
Scientific Experience
Therapeutic Areas
- CNS
- Cardiovascular
- Oncology
- Inflammation
- Metabolic disease
- Anti-infectives
Target Types
- GPCRs
- Kinases
- GTPases
- Nuclear hormone receptors
- Protein-Protein Interactions
- Covalent modifiers
- ProDrugs
Medicinal Chemistry Drug Design and Synthesis
- Lead generation strategy development and implementation
- Lead optimization for potency, selectivity and ADME profile improvement
- Establishment of novel Intellectual Property
- Library Design
- Synthetic chemistry route-scouting and troubleshooting w/on-site chemistry labs
Peptide Design and Synthesis
- Therapeutic peptide design and synthesis (linear, cyclic and stapled)
- Skilled in difficult and complex peptide and peptidomimetic synthesis
- Peptide conjugate design, synthesis, purification, and characterization
- Peptide macrocycle library design, synthesis and purification
- Synthesis of unnatural amino acids, peptoid building blocks, and novel linkers
- Synthesis of disulfide-rich peptides and triazole-bridged peptides
- Peptide lead optimization for potency, selectivity and ADME profile improvement
- Establishment of novel Intellectual Property
- Peptide solubility screening
- Parallel automated synthesizers and purification instrumentation for high-throughput
- Dedicated peptide purification team
- Process development and scaleup for animal studies
Large Molecule Drug Discovery Support
Technical project leadership support, working closely with the execution team in Shanghai for:
- Reagent generation (e.g. cell lines and proteins) for antibody discovery and screening
- Antibody discovery through phage display and hybridoma technologies
- Antibody engineering, including affinity maturation and humanization
- High throughput screening for specific binding, affinity or functional properties
- In vitro proof of concept studies, including biochemical and cell based functional assays
- Scale-up, QC and analytical characterization of lead antibodies
- In vivo proof of concept studies
- Cell or patient sample based functional assay development services (wet lab capability) available soon in South San Francisco location
Structure-Based Drug Design / Chemo-Informatics Capability
- Computational chemist with more than 15 years industry experience
- Lead generation and virtual screening strategies
- Lead optimization
- Selective docking of large commercial libraries
- Scaffold hopping
- Molecular dynamics, QM
- Homology modeling
- Protein design and homology modeling
Analysis and Separations Expertise
- Analytical chemist with more than 15 years industry experience
- Purity analysis, LC/MS
- Separation method development
- Preparative separation, impurity isolation
- Structure confirmation- NMR, MS
- SFC/MS analysis, EPSA
- EE/DE, chiral analysis and method development