Our proven 23,000 sqft laboratory facility in South San Francisco bridges the China-based research engine with our US-based clients. This built for purpose research facility is home to scientific ex­perts who provide technical guidance and support for early discovery research.

We offer several models for collaboration including full time equivalent (FTE) support, a US-China blended team of scientific expertise, and hourly consulting.

Our entire team is Ph.D.-qualified and our scientists each have more than 15 years of experience in the biopharmaceutical industry. We are experienced with Medicinal Chemistry, Computational Chemis­try, Peptide Chemistry, Biology, ADME, and Biologics.  The global directors of computational chemistry/structural biology and Analytical Chemistry are located at this site in South San Francisco.

Scientific Experience

Therapeutic Areas

• CNS
• Cardiovascular
• Oncology
• Inflammation
• Metabolic disease
• Anti-infectives

Target Types

• GPCRs
• Kinases
• GTPases
• Nuclear hormone receptors
• Protein-Protein Interactions
• Covalent modifiers
• ProDrugs

Medicinal Chemistry Drug Design and Synthesis

• Lead generation strategy development and implementation
• Lead optimization for potency, selectivity and ADME profile improvement
• Establishment of novel Intellectual Property
• Library Design
• Synthetic chemistry route-scouting and troubleshooting w/on-site chemistry labs

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Peptide Design and Synthesis

• Therapeutic peptide design and synthesis (linear, cyclic and stapled)
• Skilled in difficult and complex peptide and peptidomimetic synthesis
• Peptide conjugate design, synthesis, purification, and characterization
• Peptide macrocycle library design, synthesis and purification
• Synthesis of unnatural amino acids, peptoid building blocks, and novel linkers
• Synthesis of disulfide-rich peptides and triazole-bridged peptides
• Peptide lead optimization for potency, selectivity and ADME profile improvement
• Establishment of novel Intellectual Property
• Peptide solubility screening
• Parallel automated synthesizers and purification instrumentation for high-throughput
• Dedicated peptide purification team
• Process development and scaleup for animal studies

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Large Molecule Drug Discovery Support

Technical project leadership support, working closely with the execution team in China for:

• Reagent generation (e.g. cell lines and proteins) for antibody discovery and screening
• Antibody discovery through phage display and hybridoma technologies
• Antibody engineering, including affinity maturation and humanization
• High throughput screening for specific binding, affinity or functional properties
• In vitro proof of concept studies, including biochemical and cell based functional assays
• Scale-up, QC and analytical characterization of lead antibodies
• In vivo proof of concept studies
• Cell or patient sample based functional assay development services (wet lab capability) available soon in South San Francisco location

Structure-based Drug Design / Chemo-Informatics Capability

• Computational chemist with more than 15 years industry experience
• Lead generation and virtual screening strategies
• Lead optimization
• Selective docking of large commercial libraries
• Scaffold hopping
• Molecular dynamics, QM
• Homology modeling
• Protein design and homology modeling

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Analysis and Separations Expertise

• Analytical chemist with more than 15 years industry experience
• Purity analysis, LC/MS
• Separation method development
• Preparative separation, impurity isolation
• Structure confirmation- NMR, MS
• SFC/MS analysis, EPSA
• EE/DE, chiral analysis and method development

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Talk to our Team