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  • Home
  • About Us
    • About ChemPartner
    • CRO
    • CDMO
    • Accolades
    • Publications
  • Services
    • Discovery Chemistry
      • Synthetic Chemistry
      • Medicinal Chemistry
      • Library Chemistry
      • Peptide Chemistry
      • Fragment Based Screening
      • Computer Aided Drug Design
      • Analytical Services
      • Protein Structure
    • Biology & Pharmacology
      • Oncology
      • Pathology Core Facility
      • Immunology
      • Tumor Immunology
      • Cell Biology
      • In Vitro Biology
      • Neuroscience
      • Metabolic & Cardiovascular Diseases
      • Epigenetics
    • Biologics Discovery
      • Antibody Discovery
      • Protein Science
      • Biologics Analytical Services
    • DMPK / Exploratory Toxicology
      • DMPK / Exploratory Toxicology
      • Biomarkers, Preclinical & Clinical Sample Bioanalysis
      • Large molecule PK/BA services
    • Biologics CMC
      • Stable Cell Line Development
      • Process Development
      • Formulation Development
      • Aseptic Filling and Freeze-drying
      • Drug Developability / Manufacturability study
      • Final Container Extractables & Leachables Study
      • Analytical Development and Testing
      • GMP Production
    • Small Molecule CMC
      • Process R&D Services
      • Process Safety
      • Analytical Development
      • Pre-Formulation Development
      • Formulation Development
      • ICH Stability Studies
      • CMC CTD Support
      • Manufacturing
  • Blog
  • Careers
  • News & Events
  • Contact Us
  • Download Center

Chemistry at ChemPartner

Our proven 23,000 sqft laboratory facility in South San Francisco bridges the China-based research engine with our US-based clients. This built for purpose research facility is home to scientific ex­perts who provide technical guidance and support for early discovery research.

We offer several models for collaboration including full time equivalent (FTE) support, a US-China blended team of scientific expertise, and hourly consulting.

Our entire team is Ph.D.-qualified and our scientists each have more than 15 years of experience in the biopharmaceutical industry. We are experienced with Medicinal Chemistry, Computational Chemis­try, Peptide Chemistry, Biology, ADME, and Biologics.  The global directors of computational chemistry/structural biology and Analytical Chemistry are located at this site in South San Francisco.

Scientific Experience

Therapeutic Areas

  • CNS
  • Cardiovascular
  • Oncology
  • Inflammation
  • Metabolic disease
  • Anti-infectives

Target Types

  • GPCRs
  • Kinases
  • GTPases
  • Nuclear hormone receptors
  • Protein-Protein Interactions
  • Covalent modifiers
  • ProDrugs

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Medicinal Chemistry Drug Design and Synthesis

  • Lead generation strategy development and implementation
  • Lead optimization for potency, selectivity and ADME profile improvement
  • Establishment of novel Intellectual Property
  • Library Design
  • Synthetic chemistry route-scouting and troubleshooting w/on-site chemistry labs

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Peptide Design and Synthesis

  • Therapeutic peptide design and synthesis (linear, cyclic and stapled)
  • Skilled in difficult and complex peptide and peptidomimetic synthesis
  • Peptide conjugate design, synthesis, purification, and characterization
  • Peptide macrocycle library design, synthesis and purification
  • Synthesis of unnatural amino acids, peptoid building blocks, and novel linkers
  • Synthesis of disulfide-rich peptides and triazole-bridged peptides
  • Peptide lead optimization for potency, selectivity and ADME profile improvement
  • Establishment of novel Intellectual Property
  • Peptide solubility screening
  • Parallel automated synthesizers and purification instrumentation for high-throughput
  • Dedicated peptide purification team
  • Process development and scaleup for animal studies

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Large Molecule Drug Discovery Support

Technical project leadership support, working closely with the execution team in China for:

  • Reagent generation (e.g. cell lines and proteins) for antibody discovery and screening
  • Antibody discovery through phage display and hybridoma technologies
  • Antibody engineering, including affinity maturation and humanization
  • High throughput screening for specific binding, affinity or functional properties
  • In vitro proof of concept studies, including biochemical and cell based functional assays
  • Scale-up, QC and analytical characterization of lead antibodies
  • In vivo proof of concept studies
  • Cell or patient sample based functional assay development services (wet lab capability) available soon in South San Francisco location

Structure-based Drug Design / Chemo-Informatics Capability

  • Computational chemist with more than 15 years industry experience
  • Lead generation and virtual screening strategies
  • Lead optimization
  • Selective docking of large commercial libraries
  • Scaffold hopping
  • Molecular dynamics, QM
  • Homology modeling
  • Protein design and homology modeling

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Analysis and Separations Expertise

  • Analytical chemist with more than 15 years industry experience
  • Purity analysis, LC/MS
  • Separation method development
  • Preparative separation, impurity isolation
  • Structure confirmation- NMR, MS
  • SFC/MS analysis, EPSA
  • EE/DE, chiral analysis and method development

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ChemPartner is a leading research organization providing high-quality and cost-effective services for the pharmaceutical and biotechnology industry.

Get started today.

Contact Us
  • ChemPartner Co., Ltd.
  • No. 5 Building, 998 Halei Road, Zhangjiang Hi-Tech Park Pudong New Area, Shanghai China, 201203
  • +86 21 5132 0088
  • contact@chempartner.com

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