The molecular basis of epigenetics, the study of heritable phenotype changes that do not involve alterations in the DNA sequence, mainly includes the modification of DNA and histones, which lead to the up-regulation or down-regulation of the related gene expression. It is an important part of regulating the cell life cycle. In addition to genomics, epigenetics provides further understanding for development, aging, and many diseases. Moreover, epigenetic targets open up a broader space for new drug discovery.
ChemPartner’s in vitro Biology team has exclusively developed more than 100 epigenetic enzymatic assays, which fully cover histone methylation and demethylation, histone acetylation and deacetylation, DNA methylation, and methylation/acetylation reader proteins. The established epigenetic enzyme panel provides comprehensive assay support for early drug discovery.
ChemPartner Epigenetics Panel