Pharmacokinetics

AAALAC and OLAW accredited animal facilities with access to broad ranges of animal species
State of the art instruments
Extensive experiences in PK model development with comprehensive in vivo technique such as surgical operation and animal care
Formulation support for in vivo studies including formulation screen, development and formulation recommendation for various species and strains
PK/PD data analysis, modeling, and simulation
Regulatory filing support

Mouse, rat, Guinea pig, gerbil, hamster, rabbit, ferret, dog, monkey and mini pig

IV, PO, SC, IP, IM, IV infusion, SC infusion, intranasal (IN) and intracerebral ventricular (ICV), rectal, topical administration etc.

Tail vein, foot dorsal vein, femoral vein, facial vein, submandibular, CSF (cisternae; spinal cord), tear, lymph, all tissues etc.

Portal vein cannulation
Mesenteric lymph duct cannulation
Bile duct cannulation (rat, dog, and monkey)
Intraduodenal administration
Terminal CSF collection (mice) and survival CSF collection ( rat, mini pigs, dog, and monkey)

Blood, plasma, urine, tissue, CSF, brain, sciatic nerve, DRG, lymph node, bone marrow and all other tissues.

Clear solution strategy for IV dosing
Suspension formulation strategy for chronic toxicity study
Simulated intestinal fluid (SIF) and simulated gastric fluid (SGF) dilution study for in vivo precipitation and super-saturation prediction
Advanced formulation approach (microsuspension, nanosuspension or solid dispersion)