Pharmacology, PK/PD, and Exploratory Toxicity

Pharmacology, PK/PD, and Exploratory Toxicity

Mouse, rat, monkey SC, IP, IV bolus, IV infusion Bio-analytical development PK/PD modeling and simulation In vitro stability in biological matrices Single dose, repeated dose, dose range finding in rats and monkeys Efficacy studies 160+ cell line xenografts and 270+...
Pharmacology, PK/PD, and Exploratory Toxicity

ADC Release and Stability Testing

Our capabilities include the following assays: Antigen binding activity determination: ELISA, FACS Drug to Antibody ratio (DAR) determination: UV-Vis, LC-MS, HPLC-HIC, iCIEF, etc. Residues of free drug determination: LC-MS/MS In vitro efficacy and bioactivity...
Pharmacology, PK/PD, and Exploratory Toxicity

Case Study on T-DM1 (Kadcyla)

Trastuzumab-DM1 (T-DM1; biosimilar of Kadcyla®) was synthesized and was tested in an in vitro efficacy assay employing an in vivo xenograft model. The following results demonstrate the in-house T-DM1 has comparable tumor inhibition activity and in vivo PK profiles...
Pharmacology, PK/PD, and Exploratory Toxicity

Affinity Maturation

Apart from antibody humanization and antibody discovery from phage display, ChemPartner’s antibody engineering department also offers sequence optimization and affinity maturation services.  We provide customized affinity maturation strategies [random mutagenesis...