PK/PD Study in Tumor Bearing Animal

PK/PD Correlation in SU-DHL-6 CDX Phosphorylation of downstream target Y (PD marker) inversely correlated with the concentration of Compound X in the tumor (PK)

CDX Models

SubcutaneousDisease# of ModelsModelsBladder Cancer4RT112; HT-1376; RT112 84; UM-UC-3 Breast Cancer14MDA-MB-231(x);MDA-MB-468(x2); MDA-MB-436; DU4475; HCC70; MX-1(TNBC total 6);MCF-7(x); ZR-75-1;BT-474(x); T-47D(x); HCC1569; HCC1954;...
MOA Study

MOA Study

In addition to assay development and compound profiling, ChemPartner’s in vitro biology team has the robust expertise related to the enzymology necessary to conduct in-depth research on the mechanism of action (MoA) for compounds, including reversibility studies,...
MOA Study

High Throughput Screening

ChemPartner’s possesses the world’s leading automated systems and provides customized high-throughput screening services for our clients. These services include the high-throughput biochemical/cellular assay development or assay validation, clients’ library compound...
MOA Study

Customized Assay Development

ChemPartner’s in vitro biology team has extensive experience in assay development and has the capability to provide a variety of customized assays for our customers.   Major Assay Technologies: Fluorescence Detection Chemiluminescence Detection FRET/TR-FRET...