An essential part of successful drug development is safety; therefore, many companies are now using safety pharmacology and profiling earlier in the drug discovery process to identify and mitigate off-target related adverse drug reactions and achieve optimal...
PK/PD Correlation in SU-DHL-6 CDX Phosphorylation of downstream target Y (PD marker) inversely correlated with the concentration of Compound X in the tumor (PK)
In addition to assay development and compound profiling, ChemPartner’s in vitro biology team has the robust expertise related to the enzymology necessary to conduct in-depth research on the mechanism of action (MoA) for compounds, including reversibility studies,...
ChemPartner’s possesses the world’s leading automated systems and provides customized high-throughput screening services for our clients. These services include the high-throughput biochemical/cellular assay development or assay validation, clients’ library compound...
ChemPartner’s in vitro biology team has extensive experience in assay development and has the capability to provide a variety of customized assays for our customers. Major Assay Technologies: Fluorescence Detection Chemiluminescence Detection FRET/TR-FRET Detection...
ChemPartner has provided a variety of radiometric assay services to a large number of customers and accumulated a wealth of experience in the last two decades. There are four types of radioisotopes ([3H], [14C], [33P], [35S]) available. The key assay formats include...
The coronavirus SARS-CoV-2 (often referenced as COVID-19) is an RNA virus with much higher mutation rates than a DNA virus. Therefore, in the battle against the COVID-19 epidemic, in addition to quarantine and vaccine therapy development, a deeper understanding of...
ChemPartner’s in vitro biology team has developed KRAS assays series for different screening strategies, which facilitate the identification of different types of inhibitors such as KRAS activity inhibitors and SOS1 activity inhibitors. We also conducted an in-depth...
ChemPartner’s in vitro biology team has developed a series of assays for protein ubiquitin-proteasome system, including deubiquitination enzyme activity, E1 activating enzyme activity, E2 conjugating enzyme activity, and the E3 ligase activity assays, which can be...
