Adjuvant induced arthritis in rats (AIA)

Autoimmune Disease and Inflammation In Vivo Models

Respiratory Disease OVA-induced asthma in mice HDM-induced asthma in mice  Bleomycin-induced lung fibrosis in mice Rheumatoid Arthritis Collagen-induced arthritis in rats (CIA) Adjuvant-induced arthritis in rats (AIA) Multiple Sclerosis (MS) MOG-induced EAE in mice...
Adjuvant induced arthritis in rats (AIA)

Th Subsets Differentiation (Th1/2/17/Treg) Assays

Primary T Cell Differentiation Assay Species: human and mouse Type: Th1, Th2, Th17, Treg Cell Source: Naïve CD4+ T cell from hPBMC or mouse spleen tissue   Th1: IFN-g+ Cells% by FACS   Th17: IL-17a Conc. by ELISA   Treg: CD25+Foxp3+ Cells% by FACS...
Adjuvant induced arthritis in rats (AIA)

Mixed Lymphocyte Reaction (MLR) Assay

The MLR assay is considered the ‘gold standard’ T cell functional assay for the test of T cell immune checkpoint inhibitors Dendritic cells co-cultured with allogeneic CD3+ T cells Readouts: IFN-γ and IL-2 production Suitable to test both antibodies and small...