In addition to assay development and compound profiling, ChemPartner’s in vitro biology team has the robust expertise related to the enzymology necessary to conduct in-depth research on the mechanism of action (MoA) for compounds, including reversibility studies,...
ChemPartner’s possesses the world’s leading automated systems and provides customized high-throughput screening services for our clients. These services include the high-throughput biochemical/cellular assay development or assay validation, clients’ library compound...
ChemPartner’s in vitro biology team has extensive experience in assay development and has the capability to provide a variety of customized assays for our customers. Major Assay Technologies: Fluorescence Detection Chemiluminescence Detection FRET/TR-FRET Detection...
ChemPartner has provided a variety of radiometric assay services to a large number of customers and accumulated a wealth of experience in the last two decades. There are four types of radioisotopes ([3H], [14C], [33P], [35S]) available. The key assay formats include...
The coronavirus SARS-CoV-2 (often referenced as COVID-19) is an RNA virus with much higher mutation rates than a DNA virus. Therefore, in the battle against the COVID-19 epidemic, in addition to quarantine and vaccine therapy development, a deeper understanding of...
ChemPartner’s in vitro biology team has developed KRAS assays series for different screening strategies, which facilitate the identification of different types of inhibitors such as KRAS activity inhibitors and SOS1 activity inhibitors. We also conducted an in-depth...
ChemPartner’s in vitro biology team has developed a series of assays for protein ubiquitin-proteasome system, including deubiquitination enzyme activity, E1 activating enzyme activity, E2 conjugating enzyme activity, and the E3 ligase activity assays, which can be...
G Protein Coupled Receptors (GPCR), nuclear hormone receptors, ion channels, and transporters are all important drug targets. More than 50% of drugs targets are receptors; therefore, they have become the most important drug target. GPCR targeted drugs have a wide...
The molecular basis of epigenetics, the study of heritable phenotype changes that do not involve alterations in the DNA sequence, mainly includes the modification of DNA and histones, which lead to the up-regulation or down-regulation of the related gene expression....
Kinases play essential roles in cell signal transduction, thereby regulating various physiological functions of cells; therefore, kinases are an essential drug target for many diseases. ChemPartner’s in vitro biology team has established nearly 200 kinase assays by...
