KRAS

KRAS

ChemPartner’s in vitro biology team has developed KRAS assays series for different screening strategies, which facilitate the identification of different types of inhibitors such as KRAS activity inhibitors and SOS1 activity inhibitors. We also conducted an in-depth...
KRAS

Ubiquitin & PROTAC

ChemPartner’s in vitro biology team has developed a series of assays for protein ubiquitin-proteasome system, including deubiquitination enzyme activity, E1 activating enzyme activity, E2 conjugating enzyme activity, and the E3 ligase activity assays, which can be...
KRAS

GPCR, NR, Ion-channel, Transporter

G Protein Coupled Receptors (GPCR), nuclear hormone receptors, ion channels, and transporters are all important drug targets. More than 50% of drugs targets are receptors; therefore, they have become the most important drug target. GPCR targeted drugs have a wide...
KRAS

Epigenetics

The molecular basis of epigenetics, the study of heritable phenotype changes that do not involve alterations in the DNA sequence, mainly includes the modification of DNA and histones, which lead to the up-regulation or down-regulation of the related gene expression....
KRAS

Kinases

Kinases play essential roles in cell signal transduction, thereby regulating various physiological functions of cells; therefore, kinases are an essential drug target for many diseases. ChemPartner’s in vitro biology team has established nearly 200 kinase assays by...