Featured Services
Immunogen and Antigen Preparation
Recombinant protein production and cell line development
Peptide and compound design and synthesis
DNA In vivo transfection
Binding Assays and Bioassays
Well-established assays
Assay development and optimization for hybridoma screening
Extensive functional assays for antibody characterization
| Item | Well Established Assays |
| Protein-based Functional Assays | Ligand binding/blocking assay (Protein based ELISA or cell based FACS) |
| Cell based or protein based enzymatic assays (such as CD38, CD39, CD73, complement pathway…) | |
| Cell-based Functional Assays 30 + Established assays Recombinant cell lines Endogenous cell lines Primary human PBMC Primary NHP cells Primary rodent cells | Ligand binding/blocking assay(FACS) |
| Proliferation assay | |
| Apoptosis assay | |
| Mixed Lymphocyte Reaction Assay | |
| T Cell Stimulation Assay | |
| Cell adhesion blocking assay | |
| Migration assay | |
| Soft agar colony formation assay | |
| Phosphorylation/signaling assay | |
| Luciferase reporter assay | |
| Cytokine releasing assay | |
| FLIPR assay | |
| Antibody internalization assay | |
| ADCC/CDC | |
| Whole blood assay | |
| Lymphocytes/tumor cell co-culture killing assay |
AAALAC accredited and licensed animal facility
Animal Immunization
Multiple Specific Pathogen Free (SPF) species: mouse, rat, hamster, rabbit
CPSJ mice with superior immune response
Transgenic mice for fully human antibody generation
Customized program based on target biology and assays
Hybridoma Development
High fusion efficiency electrofusion
ELISA/Acumen/Mirrorball screening and customized functional screening
Isotyping/epitope binning by ELISA/Octet and affinity ranking by Biacore/Octet
High throughput SPR/Epitope binning by LSA Carterra
Antibody Production
Working and master cell banking
In vitro production and affinity purification
Low endotoxin purification for bioassay and in vivo studies
Rigorous quality and functional characterization
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