Target-Specific Assay Panels – Small Molecule Targets

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ID

Target

Biochemical Assay

Cell-based Assays

1

IDO1

IDO1 enzyme activity

IFNγ-induced cellular IDO1 in Hela cells; 

IDO1 transient/stable transfection in HEK293 cells

2

TDO2

TDO2 enzyme activity

TDO2 transient/stable transfection in HEK293 cells

3

ARG1

ARG1 enzyme activity

NA

4

A2A

A2A binding activity

Cellular cAMP; 

NECA-mediated T cell functional (TNFα and p-CREB level)

5

A2B

NA

Cellular AMP

6

STING

STING thermal shift assay

STING/TBK1/IRF3 pathway by Western blot

7

ALK4

ALK4 Kinase activity

NA

8

ALK5

ALK5 Kinase activity

TGFβ1-induced SBE (SMAD binding element) reporter activity 

9

PI3Kγ

PI3Kγ Kinase activity

p-AKT by ELISA

10

PI3Kδ

PI3Kδ Kinase activity

p-AKT by ELISA

 

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