Behavioral Pharmacology

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Neurodegeneration

  • Alzheimer’s Disease – 5x Familial AD Transgenic Mice
    • Biomarkers, pathology, EEG, behavioral tests, LTP in brain slice
  • Parkinson’s Disease – 6-OHDA Rats
    • Apomorphine or L-DOPA challenged rotation
    • L-DOPA induced dyskinesia in 6-OHDA rats
    • Reserpine-induced dyskinesia in rats
    • Harmaline/tacrine-induced tremor in mice and rats
  • Hearing Loss – Noise/Chemical-Induced
    • Inner ear local delivery and sampling
    • ABR tuning curve
    • Frequency mapping
  • Ophthalmic Degeneration Visible Light-induced Retinal Damage, Rodents
    • Electroretinography (ERG)

 

Neuropsychiatry

  • Depression
    • Forced swim test, rats and mice
    • Tail suspension, mice
  • Anxiety
    • Vogel conflict test, rats
    • Marble test, mice
    • Elevated plus maze, mice and rats
    • Sucrose preference
  • Sleep/Wake and Circadian Rhythm
    • Polysomnograph
    • Spontaneous Activity with vibration pattern recognition
  • CNS Safety Pharmacology
    • sLMA
    • Modified Irwin
    • Pharmaco-EEG in rodents and dogs

 

Pain

  • Inflammatory Pain
    • CFA-induced, rats
    • Formalin-induced, rats
  • Visceral Pain
    • Acetic acid writhing, rodents
  • Neuropathic Pain
    • CCI
    • SNL
    • STZ-induced diabetic neuropathy
    • Chemotherapy-induced neuropathy (Vincristine, Paclitaxel)
  • Readouts
    • Von Frey, Randall-Selito
    • Tail flick, hot/cold plate

 

Epilepsy

  • Chemically-induced seizure
    • PTZ-induced, mice
    • LiCl and pilocarpine-induced status epilepticus, rats
  • Electrically-induced seizure
    • 6 Hz electroshock-induced, mice
    • Maximal electroshock-induced (MES), mice
    • Maximal electroshock threshold (MEST), rodents
  • Dravet mice: genetic seizure

 

Rare Disease

  • MLD mice
  • Twitcher mice
  • Fabry mice

 

Automatic Analysis of Spontaneous Behavior

Laboras Measurement of Formalin-induced Pawlicks

 

Hindlimb Licking Number (Total)

 

AAV-GFP Targeted Expression in Cochlea of C57 Mice

 

 Laser confocal scanning microscopy (LCSM)

 

Neuropathic Pain

 

CCl Model

 

Chung Model

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