Bispecific Antibodies

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We have developed multiple assays targeting the different war heads of the bispecific antibody and the Fc region.

  • Similar PK profile in SD rat for both antibodies
  • Fast clearance in monkey

Bispecific Ab – Non-specific PK in Rats and Targeted Mediated Disposition in Cyno Monkeys

Purpose: to evaluate the non-linear PK in cyno monkeys and linear PK in SD rats for bispecific antibodies

 

Study Design

  • Dose
    • IV Bolus: 5 mg/kg in SD rats
    • IV Bolus: 1, 2.5, or 7.5 mg/kg in cyno monkeys
  • Sampling
    • Serum collection up to 28 days for rats and up to 42 days for cyno monkeys post dosing

SD Rats (n=4)

 

Cynos (n=3)

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PuDong New Area
Shanghai China, 201203

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