In Vitro ADME

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At lead generation and optimization stages, our in vitro ADME assay screening is often used. 

Metabolic Stability and Metabolite Identification

  • Liver microsomes
  • Hepatocytes
  • Liver S9 fractions
  • Plasma and whole blood
  • Metabolic pathway and metabolites identification

Drug-Drug Interactions

  • CYP450 inhibition
  • CYP450 induction
  • CYP450 phenotyping

Distribution

  • Plasma protein binding
  • Blood partitioning
  • Caco-2 permeability
  • MDCK MDR1 permeability 
  • MDCK BCRP permeability

Physical Chemical Properties

  • Solubility and Log D (pH7.4)
  • Chemical stability
  • Particle size

Headquarters

1F & 3F, Block A
2829 JinKe Road
Zhangjiang Hi-Tech Park
PuDong New Area
Shanghai China, 201203

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Contact Us

China: +86 21 5132 0088
US: +1 650 419 9974
Europe: +45 4586 9000
Japan: +81 03 5403 6975

contact@chempartner.com