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  • Specific Pathogen Free (SPF) animals and multiple species/strains such as SJL mice and SD rats
    • New Zealand White rabbit are available for immune phage library approach
  • Animal strains with superior immune response to highly conserved and multi-transmembrane protein targets
  • Extensive experience in using of fully human transgenic mice 
  • Comprehensive immunization strategies including hock and repetitive immunization at multiple sites (RIMMS) are available    
  • Novel immune tolerance breaking technology for high homology and conservative antigens
  • Extensive experience with genetic immunization with Gene Gun and in vivo electroporation
  • Successful experience in antibody generation against multi-transmembrane domain proteins like GPCR/ion channel, high homology, and other challenging targets
  • High throughput protein-based and cell-based screening platforms such as Mirrorball and Acumen are well established
  • Well established binding, receptor-ligand blocking, and cell-based functional assays 
Target Class Homology Size of ECD Immunization Strategy # of Binders # of Functional Clones
GPCR (C5aR)  >80% 37+17+27+17 aa DNA & Cell 46 10
GPCR Heterodimer 98%/91% 122 kDa + 90 kDa Protein 78 8
GPCR Undisclosed Undisclosed DNA + nanodisc/cell +nanodisc 5 5
GPCR Undisclosed 35+5+19+5 aa  Cell  34 17
GPCR (Apelin Receptor)  ~60% 26+10+28+14 Dendritic cell/cell ~200 ~15
NKG2A >90% homology 17 kDa Protein + Cell/DNA + Cell 16 7
TNFR Family 96% 50 aa Protein/Cell 29 Only look for binders
Type I Transmembrane 97% ~70 kDa DNA, Cell, Protein 210 13
RTK Family 95% ~66 kDa Protein + Cell/DNA + Cell 93 4
Integrin Family  93%/92% 250 kDa Protein, DNA 37 17
Ion Channel 92%/60% 13 + 34 aa DNA + Protein/Cell + Protein/Protein 88 14
Multi-transmembrane 87%/80% 15 + 10 aa Cell 55 Only look for binders
Multi-transmembrane 100% ECL1 53 + 24 aa DNA + Cell 39 14

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