Manufacturing Process Development and Scale-up

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  • Cell culture process technology platform provides for the optimization of media, seeding densities, feeding and bioreactor process control strategies to maximize expression, and enhances process reproducibility and facilitate scale-up
  • Adaption of cell line to suspension culture process
  • Adaption of cell line to serum-free/animal protein-free media
  • Media optimization and evaluation
  • Development of fed-batch bioreactor process
  • Cell culture characterization and optimization
  • Scale-up
  • Analysis of risk and cost benefits for various types of cell culture processes

 

Cell Culture Systems

  • Flasks (all types)
  • Spinner/shake flasks
  • Wave- and stir-form bioreactors
  • 3L and 15L bioreactors (Applikon)
  • Wave-form Bioreactors
    • 2L – 25L capacity (GE)
  • Single-use bioreactor (Hyclone & GE)
    • 1 x 50L
    • 1x200L
    • 1x250L
  • Cell culture analyzers
  • Bioprofile Flex2 (Nova Biomedical)
  • Bioprofile 400 (Nova Biomedical)
  • Vi-cell (Beckman Coulter)
  • Cell culture clarification
  • Depth filtration
  • Centrifugation

 

 

Downstream Process Platform

  • Affinity chromatography 
  • Cation or Anion exchange chromatography 
  • Hydrophobic chromatography 
  • Mixed mode chromatography 
  • Depth filtration system
  • 0.22 μm filtration system
  • Nanofiltration
  • Ultra-filtration and diafiltration
  • Virus inactivation system
  • Membrane chromatography
  • Periodic counter-current chromatography (PCC)
  • Akta Avant, Akta Pure, Crossflow
  • Akta Pilot
  • Akta Ready, Akta Process
  • Automatic UFDF system (Pall, Merck)
  • Scale up tool and tech transfer tools

 

 

Chromatography

 

Normal Flow Filtration: Vmax and Pmax

 

TFF: Cross-flow

 

Headquarters

1F & 3F, Block A
2829 JinKe Road
Zhangjiang Hi-Tech Park
PuDong New Area
Shanghai China, 201203

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Contact Us

China: +86 21 5132 0088
US: +1 650 419 9974
Europe: +45 4586 9000
Japan: +81 03 5403 6975

contact@chempartner.com