Pharmacokinetics

Service Pages

Questions?

Home 5 Service 5 Pharmacokinetics

ChemPartner has conducted 120-150 PK studies per week and served many pharmacokinetics (PK) clients.

  • AAALAC and OLAW accredited animal facilities with access to broad ranges of animal species
  • State-of-the-art instruments
  • Extensive experience in PK model development with comprehensive in vivo techniques such as surgical operation and animal care
  • Formulation support for in vivo studies including formulation screening, development, and formulation recommendation for various species and strains
  • PK/PD data analysis, modeling, and simulation
  • Regulatory filing support

 

Animal Species

  • Mouse, rat, guinea pig, rabbit, dog, monkey, and mini pig

 

Dose Route

  • IV, PO, SC, IP, IM, IV infusion, SC infusion, intranasal (IN), intratracheal (IT) and intracerebral ventricular (ICV), rectal, AZ pump, topical administration etc.

 

Sampling

  • Tail vein, jugular vein, facial vein, submandibular, CSF (cisternae; spinal cord), tear, lymph, all tissues etc.

 

Comprehensive Surgery Techniques

  • Portal vein cannulation
  • Mesenteric lymph duct cannulation
  • Bile duct cannulation (rat, dog, and monkey)
  • Intraduodenal administration
  • Terminal CSF collection (mice) and survival CSF collection (rat, mini pigs, dog, and monkey)

 

Biological Matrix

  • Blood, plasma, urine, tissue, CSF, brain, sciatic nerve, DRG, lymph node, bone marrow and all other tissues.

 

Formulation Development

  • Clear solution strategy for IV dosing
  • Suspension formulation strategy for chronic toxicity study
  • Simulated intestinal fluid (SIF) and simulated gastric fluid (SGF) dilution study for in vivo precipitation and super-saturation prediction
  • Advanced formulation approach (microsuspension, nanosuspension or solid dispersion)

Headquarters

1F & 3F, Block A
2829 JinKe Road
Zhangjiang Hi-Tech Park
PuDong New Area
Shanghai China, 201203

w

Contact Us

China: +86 21 5132 0088
US: +1 650 419 9974
Europe: +45 4586 9000
Japan: +81 03 5403 6975

contact@chempartner.com