ServicesTranslational BiologyIn Vitro PharmacologyTarget-Specific AssaysSmall Molecule Target Specific Assays
Small Molecule Target Specific Assays
ID | Target | Biochemical Assay | Cell-based Assays |
1 | IDO1 | IDO1 enzyme activity | IFNγ-induced cellular IDO1 in Hela cells; IDO1 transient/stable transfection in HEK293 cells |
2 | TDO2 | TDO2 enzyme activity | TDO2 transient/stable transfection in HEK293 cells |
3 | ARG1 | ARG1 enzyme activity | NA |
4 | A2A | A2A binding activity | Cellular cAMP; NECA-mediated T cell functional (TNFα and p-CREB level) |
5 | A2B | NA | Cellular AMP |
6 | STING | STING thermal shift assay | STING/TBK1/IRF3 pathway by Western blot |
7 | ALK4 | ALK4 Kinase activity | NA |
8 | ALK5 | ALK5 Kinase activity | TGFβ1-induced SBE (SMAD binding element) reporter activity |
9 | PI3Kγ | PI3Kγ Kinase activity | p-AKT by ELISA |
10 | PI3Kδ | PI3Kδ Kinase activity | p-AKT by ELISA |
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