Pre-Formulation Development
- Salt selection
- Polymorph screening
- Thermal properties
- Solubility profiling
- Hygroscopicity
- Microscopy and morphology
- Crystallinity evaluation
- Flowability
- Particle size and distribution measurement
- Bulk and tap densities
- Log P / Log D and pKa determination Log P / Log D and pKa
- Solid and solution state stability
- Excipient compatibility