MOA Study
Mechanism of action studies that establish target engagement rather than infer it. We combine cellular target engagement, pathway readouts and selectivity profiling to show what your compound does inside a cell — and, just as usefully, what it does not do.
OVERVIEW
Everything a sponsor evaluating an outsourced biologics CMC partner needs to know — from capacity to compliance.
In addition to assay development and compound profiling, ChemPartner’s in vitro biology team has the robust expertise related to the enzymology necessary to conduct in-depth research on the mechanism of action (MoA) for compounds, including reversibility studies, competition studies, and kinetic analysis (Ki, kon, koff, kinact determination).
Kinetic Analysis
Time-dependent Inhibition
Slow-off vs Irreversible Cmpds
Ki, kinact Determination
Modality of Inhibition
Competitive
Non-Competitive
Un-Competitive
