Animal: BALB/c mice, female, 7.5 weeks

Modeling: IMQ painted on shaved back skin daily

Reference Drug: Tofacitinib, p.o., BID

Readouts: Body weight, PASI score, skin thickness, pathology

PASI Score Criterial: Erythema, scale, and thickness

0: no; 1: mild; 2: moderate; 3: sever; 4: marked