Fully Human Therapeutic mAb Discovery
Fully human therapeutic antibody discovery from our proprietary naive phage library — roughly 10^11 in diversity, with V-genes amplified from diverse healthy donors and every V-gene family cloned individually to match the natural human repertoire. Independent VH and VL libraries let affinity maturation proceed by chain shuffling.
- ChemPartner’s proprietary fully human naïve phage library with diversity ~10^11. Efficient library selection and screening with high-throughput robotics.
- All V-genes were amplified with high fidelity from diverse healthy donors. Stringent cloning procedures ensure a high percentage of functional clones in the library.
- Independent VH, VL libraries maximize V-gene recovery and facilitate subsequent affinity maturation with chain shuffling
- All V-gene families are individually cloned and assembled, maximizing library diversity and reducing gene bias due to PCR cloning.
- First major naïve antibody library built with predefined V-gene composition to match the human immune repertoire
CP naïve library V-gene composition matches the natural repertoire.
