Resource Category: Publications

Ubiquitin-conjugating enzyme UbcH10 promotes gastric cancer growth and is a potential biomarker for gastric cancer

Wu X, Zhou H, Hu G. Oncol Rep. 2016 Aug;36(2):779-86. doi: 10.3892/or.2016.4906. Epub 2016 Jun 23.

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton’s Tyrosine Kinase with Improved Druglike Properties

Rudolph J, Murray LJ, Ndubaku CO, O'Brien T, Blackwood E, Wang W, Aliagas I, Gazzard L, Crawford JJ, Drobnick J, Lee W, Zhao X, Hoeflich KP, Zhang H, Heise CE, Oh A, Ong CC, La H, Chakravarty P, Chan C,

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety

Ndubaku CO, Crawford JJ, Aliagas I, Murray LJ, Tay S, Wang W, Heise CE, Hoeflich KP, La H, Mathieu S, Mintzer R, Ramaswamy S, Rouge L, Rudolph J. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox

Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists

Deng Q, et al. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2958-62. doi: 10.1016/j.bmcl.2015.05.036. Epub 2015 May 21.

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

Rudolph J, Murray LJ, Ndubaku CO, O'Brien T, Blackwood E, Wang W, Aliagas I, Gazzard L, Crawford JJ, Drobnick J, Lee W, Zhao X, Hoeflich KP, Zhang H, Heise CE, Oh A, Ong CC, La H, Chakravarty P, Chan C,
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