Pharmacokinetics - ChemPartner

ChemPartner has conducted 120-150 PK studies per week and served many pharmacokinetics (PK) clients.

AAALAC and OLAW accredited animal facilities with access to broad ranges of animal species
State-of-the-art instruments
Extensive experience in PK model development with comprehensive in vivo techniques such as surgical operation and animal care
Formulation support for in vivo studies including formulation screening, development, and formulation recommendation for various species and strains
PK/PD data analysis, modeling, and simulation
Regulatory filing support

Animal Species

Conventional administration routes: IV, PO (capsule & tablet, etc.), SC, IP, IM, topical administration
Special Clinical or Research Application: IV infusion, SC infusion, intranasal (IN), rectal, retro-orbital injection, intravitreal injection, intrathecal injection
Advanced methods: AZ pump, intracerebroventricular (ICV), intratracheal (IT)

Venous: Tail vein, jugular vein, facial vein and submandibular
Cerebrospinal fluid (CSF): Cisternae magna puncture, spinal cord puncture
Bodily fluids/samples: Tear collection, lymph collection, urine collection, feces collection
In-life tissue biopsy: Adipose, muscle, liver, kidneys, etc.
Brain region-specific sampling
Intraocular region sampling

Portal vein cannulation
Mesenteric lymph duct cannulation
Bile duct cannulation (mouse, rat, dog, and monkey)
Enteral administration (duodenum, jejunum, ileum, colon, rectum)
Terminal CSF collection (mice) and survival CSF collection (rat, mini pigs, dog, and monkey)

Blood, plasma, urine, tissue, CSF, brain, sciatic nerve, DRG, lymph node, bone marrow and all other tissues.

Clear solution strategy for IV dosing
Suspension formulation strategy for chronic toxicity study
Simulated intestinal fluid (SIF) and simulated gastric fluid (SGF) dilution study for in vivo precipitation and super-saturation prediction
Advanced formulation approach (microsuspension, nanosuspension or solid dispersion)