DMPK-In-Vitro-ADMET.pdf

In-vitro ADME assays are critical for gaining insight into metabolism and potential drug interactions. Moving quickly through drug discovery and development saves you time and money. ChemPartner has industry-leading turnaround times for data to help our clients make risk-based decisions on the drug-like properties of hits and lead molecules quickly.

Metabolic Stability

Comprehensive metabolic stability and payload release assessment across diverse biological matrices:

• Biological fluids: Plasma/serum, whole blood

• Subcellular fractions: Microsomes, cytosol, S9 fraction, lysosomes, GSH

• Primary cells & cell lines: Primary hepatocyte

• Recombinant & engineered systems: CYPs, UGTs, AO

Drug-Drug Interactions

• CYP450 inhibition

• CYP450 induction

• CYP450 phenotyping

• Time dependent inhibition

• Ki/Kinact

• SLC transporter substrate and inhibitor

• ABC transporter substrate and inhibitor

Transporter Assays 

• Caco-2

• MDCK-MDR1

• MDCK-BCRP

• MDCK-MDR1/BCRP

Protein Binding Assays

• Plasma protein binding (ED and UC)

• Unbound fraction in other diversified matrices

• RBC partitioning

Physical Chemical Properties

• Solubility and Log D (pH7.4)

• Chemical stability

• Particle size