Featured Services
A curated view of the biologics discovery capabilities clients ask for most — antibody discovery and engineering, protein production, developability assessment and conjugation support. Use it to find the right entry point, then go deeper on the capability your program needs.
Immunogen and Antigen Preparation
- Recombinant protein production and cell line development
- Peptide and compound design and synthesis
- DNA In vivo transfection
Binding Assays and Bioassays
- Well-established assays
- Assay development and optimization for hybridoma screening
- Extensive functional assays for antibody characterization
| Item | Well Established Assays |
| Protein-based Functional Assays | Ligand binding/blocking assay (Protein based ELISA or cell based FACS) |
| Cell based or protein based enzymatic assays (such as CD38, CD39, CD73, complement pathway…) | |
| Cell-based Functional Assays 30 + Established assays Recombinant cell lines Endogenous cell lines Primary human PBMC Primary NHP cells Primary rodent cells | Ligand binding/blocking assay(FACS) |
| Proliferation assay | |
| Apoptosis assay | |
| Mixed Lymphocyte Reaction Assay | |
| T Cell Stimulation Assay | |
| Cell adhesion blocking assay | |
| Migration assay | |
| Soft agar colony formation assay | |
| Phosphorylation/signaling assay | |
| Luciferase reporter assay | |
| Cytokine releasing assay | |
| FLIPR assay | |
| Antibody internalization assay | |
| ADCC/CDC | |
| Whole blood assay | |
| Lymphocytes/tumor cell co-culture killing assay |
AAALAC accredited and licensed animal facility
Animal Immunization
- Multiple Specific Pathogen Free (SPF) species: mouse, rat, hamster, rabbit
- CPSJ mice with superior immune response
- Transgenic mice for fully human antibody generation
- Customized program based on target biology and assays
Hybridoma Development
- High fusion efficiency electrofusion
- ELISA/Acumen/Mirrorball screening and customized functional screening
- Isotyping/epitope binning by ELISA/Octet and affinity ranking by Biacore/Octet
- High throughput SPR/Epitope binning by LSA Carterra
Antibody Production
- Working and master cell banking
- In vitro production and affinity purification
- Low endotoxin purification for bioassay and in vivo studies
- Rigorous quality and functional characterization
