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Behavioral Pharmacology

Behavioral pharmacology for CNS programs that need validated, reproducible readouts. Cognition, anxiety, depression, pain and motor function paradigms run by trained handlers under controlled conditions, with exposure data alongside so behavior can be interpreted against brain concentration.

概述

Neurodegeneration

Alzheimer’s Disease – 5x Familial AD Transgenic Mice
- Biomarkers, pathology, EEG, behavioral tests, LTP in brain slice

Parkinson’s Disease – 6-OHDA Rats
- Apomorphine or L-DOPA challenged rotation
- L-DOPA induced dyskinesia in 6-OHDA rats
- Reserpine-induced dyskinesia in rats
- Harmaline/tacrine-induced tremor in mice and rats

Hearing Loss – Noise/Chemical-Induced
- Inner ear local delivery and sampling
- ABR tuning curve
- Frequency mapping

Ophthalmic Degeneration Visible Light-induced Retinal Damage, Rodents
- Electroretinography (ERG)

Neuropsychiatry

Depression
- Forced swim test, rats and mice
- Tail suspension, mice

Anxiety
- Vogel conflict test, rats
- Marble test, mice
- Elevated plus maze, mice and rats
- Sucrose preference

Sleep/Wake and Circadian Rhythm
- Polysomnograph
- Spontaneous Activity with vibration pattern recognition

中枢神经系统安全性药理学
- sLMA
- Modified Irwin
- Pharmaco-EEG in rodents and dogs

Pain

Inflammatory Pain
- CFA-induced, rats
- Formalin-induced, rats

Visceral Pain
- Acetic acid writhing, rodents

Neuropathic Pain
- CCI
- SNL
- STZ-induced diabetic neuropathy
- Chemotherapy-induced neuropathy (Vincristine, Paclitaxel)

Readouts
- Von Frey, Randall-Selito
- Tail flick, hot/cold plate

Epilepsy

Chemically-induced seizure
- PTZ-induced, mice
- LiCl and pilocarpine-induced status epilepticus, rats

Electrically-induced seizure
- 6 Hz electroshock-induced, mice
- Maximal electroshock-induced (MES), mice
- Maximal electroshock threshold (MEST), rodents