In Vitro ADME
In vitro ADME screening that catches the liabilities worth acting on. Permeability, metabolic stability, protein binding, CYP inhibition and induction, and transporter interaction — run as a tiered cascade so early compounds get triaged fast and late compounds get characterized properly.
无论您是推进临床前项目的研发，还是为后期生产做准备，我们的团队都能帮助您优化研发流程、降低规模化生产风险，并生成符合监管要求的支撑数据。
概述
In-vitro ADME assays are critical for gaining insight into metabolism and potential drug interactions. Moving quickly through drug discovery and development saves you time and money. ChemPartner has industry-leading turnaround times for data to help our clients make risk-based decisions on the drug-like properties of hits and lead molecules quickly.
Metabolic Stability
Comprehensive metabolic stability and payload release assessment across diverse biological matrices:
- Biological fluids: Plasma/serum, whole blood
- Subcellular fractions: Microsomes, cytosol, S9 fraction, lysosomes, GSH
- Primary cells & cell lines: Primary hepatocyte
- Recombinant & engineered systems: CYPs, UGTs, AO
Drug-Drug Interactions
- CYP450 inhibition
- CYP450 induction
- CYP450 phenotyping
- Time dependent inhibition
- Ki/Kinact
- SLC transporter substrate and inhibitor
- ABC transporter substrate and inhibitor
Transporter Assays
- Caco-2
- MDCK-MDR1
- MDCK-BCRP
- MDCK-MDR1/BCRP
Protein Binding Assays
- Plasma protein binding (ED and UC)
- Unbound fraction in other diversified matrices
- RBC partitioning
Physical Chemical Properties
- Solubility and Log D (pH7.4)
- Chemical stability
- Particle size
