噬菌体展示
Phage display antibody generation for targets where immunization stalls. We panel naive and immune libraries against difficult antigens — membrane proteins, conserved epitopes, defined conformational states — and deliver characterized binders ready for affinity maturation or reformatting.
概述
ChemPartner’s phage display and high throughput screening group offers streamlined services for fully human therapeutic antibody discovery and optimization, also providing coherent protein engineering, immune library construction, and screening for general biologics development. Supported by our strong analytical capabilities and infrastructures in pharmacology, DMPK, and toxicology, we are well-positioned to provide globally competitive services with significant cost reduction.
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- Fully human therapeutic mAb discovery
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- Synthetic/naïve VHH therapeutic mAb discovery
- Antibody optimization and affinity maturation
Human Naïve scFv Library
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- PBMCs isolation from 50+ diversified human donors
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- V-gene families cloning and assembling into phagemid
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- Phage library size 1010~11
Immune Library
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- Lymphocytes isolation from immunized animals
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- PBMCs from diseased human individuals
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- Multi-species (Ms, Rb, Hu, Alpaca) and diseases status
Synthetic Libraries
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- Human synthetic scFv library
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- VHH library
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- Common light chain
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- Linear and Cyclic peptide library
Antibody Affinity Maturation
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- scFv affinity libraries construction by CDR targeted mutagenesis
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- Library panning against Ag at various conditions
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- Initial screening with ELISA and off-rate ForteBio ranking
