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Resource Category: Publications

Generation and characterization of a high-affinity chimeric anti-OX40 antibody with potent antitumor activity

Yongli Yang et al. FEBS Lett. 2021 Jun;595(11):1587-1603. doi: 10.1002/1873-3468.14079. Epub 2021 Apr 28.

Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion

Yu J, Gao Y, Jin L, Konteatis Z, et al. J Med Chem. 2021 Apr 22;64(8):4430-4449. doi: 10.1021/acs.jmedchem.0c01895. Epub 2021 Apr 8.

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310

Jia Q, Li J, Kim A, Safina BS. Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310. J Med Chem. 2021 Mar 25;64(6):2953-2966. doi: 10.1021/acs.jmedchem.1c00049. Epub 2021 Mar 8.

PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma

Jianfeng Wang et al. Theranostics. 2021 Mar 12;11(11):5387-5403. doi: 10.7150/thno.42345. eCollection 2021.

Preclinical efficacy and toxicity studies of a highly specific chimeric anti-CD47 antibody

Xu Z, Gu J, Yang J, Tang Y, Wang D, Ding C, Du Y. Preclinical efficacy and toxicity studies of a highly specific chimeric anti-CD47 antibody. FEBS Open Bio. 2021 Mar;11(3):813-825. doi: 10.1002/2211-5463.13084. Epub 2021 Feb 22.

Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma

Konteatis Z, Jin L, et al. ACS Med Chem Lett. 2020 Jan 22;11(2):101-107. doi: 10.1021/acsmedchemlett.9b00509. eCollection 2020 Feb 13.

Study of the interactions of a novel monoclonal antibody, mAb059c, with the hPD-1 receptor

Jingxian Liu, Guangqiang Wang, Lei Liu, Ruijuan Wang, Yi Wu, Chen Feng, Xiaohong Zhang, Jing Jiang, Ying Gu, He Zhou, Zhihong Xu, Zhiwei Sun, Dakang Chen, Wen Tian, Tian Yang, Ken Dai, Dexin Wang. Sci Rep. 2019 Nov 28;9(1):17830. doi:

The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders

Troxler T et al. ChemMedChem. 2019 Jul 3;14(13):1238-1247. doi: 10.1002/cmdc.201900176. Epub 2019 May 21.

Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening

Han J, Lu T, Zhang Y, et al. Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening. Bioorg Chem. 2019 May;86:494-500. doi: 10.1016/j.bioorg.2019.01.035. Epub 2019 Jan 28.

Discovery of N-indanyl benzamides as potent RORγt inverse agonists

Jin Liu, Li Liu, et al. Eur J Med Chem. 2019 Apr 1;167:37-48. doi: 10.1016/j.ejmech.2019.01.082. Epub 2019 Feb 4.
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