ID	Target	Receptor Ligand Binding Blocking	Cell-based Functional Readout
1	PD1	PD1/PD-L1PD1/PD-L2	T cell activation (PBMC + CHOK1/OS8/PD-L1)Mixed Lymphocyte ReactionJurkat NFAT luciferase reporter assay
2	PD-L1	PD-L1/PD1PD-L1/B7.1	T cell activation (PBMC + CHOK1/OS8/PD-L1)Mixed Lymphocyte ReactionJurkat NFAT luciferase reporter assay
3	CTLA4	CTLA-4/B7.1CTLA-4/B7.2	T cell activation (PBMC/SEB)T cell blast / Raji co-culture
4	4-1BB	4-1BB/4-1BBL	T cell activation (CHOK1-OS8) NFkB luciferase reporter assay
5	GITR	GITR/GITRL	T cell activationNFkB luciferase reporter assay
6	LAG3	LAG-3/MHC IILAG-3/FGL1LAG-3/LSECtin	NFAT luciferase reporter assayT cell activation (PBMC/SEB)Antigen specific T cell activation
7	TIM-3	TIM-3/Phosphatidylserine	T cell activation (PBMC+CHOK1/OS8 + inducer)
8	OX40	OX40/OX40L	T cell activation NFκB reporter assay
9	TIGIT	TIGIT/CD155TIGIT/CD122	NFAT luciferase reporter assay
10	NKG2A	NKG2A/MHC	NK cell mediated cytotoxicity
11	CD70	CD70/CD27	Cytotoxicity
12	CD73	hCD73 ECD-his	CD73 Enzymatic activityAMP – T cell Suppression Internalization
13	CD47	CD47/SIPRa	Phagocytosis Hemagglutination
14	SEMA4D	SEMA4D/Plexin B1SEMA4D/Plexin B2	Cell migration Cell detachment